About Azithromycin 500mg tablets
Azithromycin 500mg demonstrates a wide range of action and is effective against various types of bacteria including gram-negative, gram-positive, aerobes, and anaerobes. There are only a few types of bacilli that demonstrate resistance to Azithromycin. This includes certain strains of streptococci, staphylococci, salmonella, and shigella.
Azithromycin is used to treat infectious diseases that affect:
- upper respiratory tract (throat, nasopharynx, and sinuses)
- lower respiratory tract (bronchi and trachea)
- genito-urinary organs
Infections of the respiratory system where Azithromycin may be prescribed:
- pneumonia (including atypical)
- scarlet fever
- otitis media
Infections affecting the urogenital organs where Azithromycin may be prescribed:
Azithromycin can also be used to treat the early stages of Lyme disease, various skin infections, and soft tissue infections (e.g., erysipelas, impetigo, and dermatitis).
As part of combination therapy, Azithromycin can be used to kill Helicobacter pylori, which causes various gastric diseases (e.g., gastritis and ulcers).
Azithromycin can be produced in various dosage forms including film-coated tablets, absorbable tablets, capsules, suspension for children, and powder for the preparation of a solution for parenteral administration. Most often Azithromycin is taken as tablets or capsules, which contain dosages equal to 125, 250mg, or 500 mg of the active substance.
When Azithromycin is originally in powder form meant for the preparation of an oral suspension, it can contain dosages of 15, 30 or 75 mg of Azithromycin per gram of powder.
While side effects associated with Azithromycin are rare, they are possible. The most common side effects are those associated with the gastrointestinal tract, which includes pain in the stomach, diarrhea, nausea, constipation, and sometimes vomiting. It is also important to remember that like any antibiotic, Azithromycin can affect the healthy intestinal microflora, which can be expressed as dysbiosis. Therefore, a course of antibiotic therapy should be immediately followed with a course of probiotics to help restore intestinal microflora.
The popularity of Azithromycin is well-represented based on the availability of a large number of cheap analogs, which litter pharmacy shelves. The usefulness of Azithromycin is wide-spread across various fields of medicine. Pediatricians, obstetrician-gynecologists, internists, dermatologists, surgeons, and many other specialties typically use Azithromycin in each respective medical practice. Azithromycin has impacted the lives of millions of patients and hundreds of thousands of doctors. It is not likely that Azithromycin is going to give up its position as a leading antibiotic.
In 2010, Azithromycin became the most frequently prescribed antibiotic in the United States. Interestingly, the popularity of Azithromycin arose from Sweden, which is a country where macrolides (a group of antibiotics to which Azithromycin belongs) are prescribed only in 3% of cases and ranked third among all outpatient antibacterial drugs.
Azithromycin has also been included in the World Health Organization list of medicines that are vital for maintaining human health.
Azithromycin is a white crystalline powder that is water soluble, belongs to the macrolide group, and is a derivative of Erythromycin.
Erythromycin was first discovered in the 1950s and immediately lent itself as a drug demonstrating a broader spectrum of therapeutic action compared with previously discovered penicillin-based drugs.
The unique properties of Azithromycin are underpinned by its pharmacokinetic effects. Azithromycin is quickly absorbed from the gastrointestinal tract. The maximum concentration of Azithromycin within blood is achieved in 2-3 hours after ingestion. However, the most surprising property of Azithromycin is the slow removal from the body. Unlike other antibacterial drugs, which typically are removed from the body within 10-12 hours, Azithromycin persists in the body at maximal concentrations in the blood and tissues for at least 24 hours. The half-life of Azithromycin is 68 hours. Thanks to this unique property, Azithromycin is prescribed as a once a day drug, whereas most other antibiotics must be taken at least every 12 hours.
The other special pharmacokinetic property that distinguishes Azithromycin from other antibiotics is highlighted by its ability to reach high concentrations at localized areas of inflammation. In tissues and cells in which an inflammatory reaction requires antibiotics, the content of Azithromycin is 10-50 times higher than in blood plasma.
One more prominent feature of Azithromycin is that even after discontinuation of therapy, a high concentration of antibiotic in the tissues persists for another 5-7 days.
Other positive features of Azithromycin include the ability to choose different dosage forms.
While taking Azithromycin, patients may also demonstrate side effects such as allergic reactions involving appearance of skin rashes or hives, which are accompanied by itching.